| 2022-02-22 19:00:0022/02/2022 | Lagarto-SE | 0 - 0 | Figueirense | N/D |
| 2022-02-22 21:30:0022/02/2022 | URT-MG | 1 - 1 | Avaí | N/D |
| 2022-02-22 21:30:0022/02/2022 | FC Cascavel | 1 - 0 | Ponte Preta | N/D |
| 2022-02-23 15:30:0023/02/2022 | Tuntum | 4 - 2 | Volta Redonda | N/D |
| 2022-02-23 19:00:0023/02/2022 | Azuriz-PR | 1 - 0 | Botafogo-SP | N/D |
| 2022-02-23 19:00:0023/02/2022 | ASA | 0 - 2 | Cuiabá | N/D |
| 2022-02-23 19:00:0023/02/2022 | Salgueiro | 0 - 3 | Santos | N/D |
| 2022-02-23 20:00:0023/02/2022 | Glória-RS | 1 - 0 | Brasil de Pelotas | N/D |
| 2022-02-23 20:30:0023/02/2022 | Tocantinópolis | 1 - 0 | Náutico | N/D |
| 2022-02-23 21:30:0023/02/2022 | Atlético Alagoinhas | 1 - 1 | CSA | N/D |
| 2022-02-23 21:30:0023/02/2022 | Sergipe | 0 - 5 | Cruzeiro | N/D |
| 2022-02-23 22:00:0023/02/2022 | Humaitá-AC | 2 - 2 | Brasiliense | N/D |
| 2022-02-24 15:30:0024/02/2022 | Nova Iguaçu | 0 - 0 | Criciúma | N/D |
| 2022-02-24 15:30:0024/02/2022 | Fluminense-PI | 2 - 0 | Oeste | N/D |
| 2022-02-24 16:30:0024/02/2022 | São Raimundo-AM | 0 - 1 | Manaus | N/D |
| 2022-02-24 19:00:0024/02/2022 | Bahia de Feira | 2 - 5 | Coritiba | N/D |
| 2022-02-24 21:30:0024/02/2022 | Campinense | 0 - 0 | São Paulo | N/D |
| 2022-03-01 15:30:0001/03/2022 | Icasa | 0 - 0 | Tombense | N/D |
| 2022-03-01 16:00:0001/03/2022 | Maricá-RJ | 0 - 1 | Guarani | N/D |
| 2022-03-01 19:00:0001/03/2022 | Moto Club | 3 - 2 | Chapecoense | N/D |
| 2022-03-01 19:00:0001/03/2022 | Pouso Alegre-MG | 2 - 0 | Paraná | N/D |
| 2022-03-01 21:30:0001/03/2022 | Mirassol | 3 - 2 | Grêmio | N/D |
| 2022-03-01 21:30:0001/03/2022 | Sousa | 1 - 1 | Goiás | N/D |
| 2022-03-02 15:30:0002/03/2022 | Ceilândia | 2 - 0 | Londrina | N/D |
| 2022-03-02 15:30:0002/03/2022 | Tuna Luso | 1 - 0 | Novorizontino | N/D |
| 2022-03-02 16:30:0002/03/2022 | Porto Velho-RO | 1 - 2 | Juventude | N/D |
| 2022-03-02 16:30:0002/03/2022 | Operário VG-MT | 1 - 2 | Sampaio Corrêa | N/D |
| 2022-03-02 19:00:0002/03/2022 | Real Noroeste-ES | 2 - 1 | Operário-PR | N/D |
| 2022-03-02 19:00:0002/03/2022 | São Raimundo-RR | 0 - 3 | Ceará | N/D |
| 2022-03-02 19:00:0002/03/2022 | Altos | 1 - 0 | Sport | N/D |
| 2022-03-02 20:00:0002/03/2022 | Rio Branco-AC | 0 - 0 | Vila Nova | N/D |
| 2022-03-02 20:30:0002/03/2022 | Grêmio Anápolis-GO | 0 - 0 | Juazeirense | N/D |
| 2022-03-02 20:30:0002/03/2022 | Trem-AP | 0 - 3 | Paysandu | N/D |
| 2022-03-02 21:00:0002/03/2022 | Costa Rica-MS | 0 - 3 | ABC | N/D |
| 2022-03-02 21:30:0002/03/2022 | Ferroviária | 0 - 1 | Vasco | N/D |
| 2022-03-02 21:30:0002/03/2022 | Portuguesa-RJ | 1 - 0 | CRB | N/D |
| 2022-03-03 15:30:0003/03/2022 | Nova Venécia-ES | 2 - 1 | Ferroviário | N/D |
| 2022-03-03 16:00:0003/03/2022 | Castanhal-PA | 1 - 1 | Vitória | N/D |
| 2022-03-03 19:00:0003/03/2022 | União Rondonópolis-MT | 0 - 3 | Atlético-GO | N/D |
| 2022-03-03 21:30:0003/03/2022 | Globo FC | 2 - 0 | Internacional | N/D |
